Intelligent Imaging Innovations (3i) Marianas SDC is a fully integrated spinning disk confocal workstation based on motorised Zeiss microscopes. It can be combined with a variety of microscopy applications, such as FRAP, Photoactivation, FLIM and TIRF sharing the same hardware (lasers, cameras). This allows for an easy and cost-effective upgrade from basic to advanced systems. Prominent features are e.g.: Yokogawa CSU-X1 spinning disk confocal head, Laserstack Launch with up to five selectable laser lines, latest EMCCD camera technology, and an option for both confocal and widefield (deconvolution) image paths. Also optional: point-scanning and whole array FRAP/photoactivation, frequency-domain FLIM module, high-speed 4D and simultaneous Dual-Camera detection, and a TIRF module.